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Obesity (especially central) is frequently associated with one or more cardiovascular risk factors, notably hyperglycaemia, hypertension, dyslipidaemia, and prothrombotic and proin ammatory changes (Table 9.2). This variable clustering of vascular risk factors is termed the metabolic syndrome (Eckel, Grundy and Zimmet, 2005) and is strongly associated with cardiovascular disease. Using current de nitions for the metabolic syndrome, the PAR for cardiovascular disease is estimated at 12 17% overall in a recent meta-analysis (Ford, 2005), and in the Framingham Heart Offspring Study at 34% for men and 16% for women (Wilson et al., 2005). As discussed in 10, the de nition, nature and signi cance of the metabolic syndrome have provoked much debate (Kahn et al., 2006; Grundy, 2007; Reaven, 2006). Also uncertain is the extent to which obesity itself contributes to cardiovascular disease, and how much of this effect is mediated through its in uences on other components of the syndrome. The issue is clouded by methodological dif culties, including inconsistencies in the de nitions of metabolic syndrome and of central obesity. One approach, focusing on measures of central obesity, has identi ed the threshold levels for cardiovascular risk mentioned above.

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Jan 19, 2016 · Convert Tiff file into PDF file using iTextSharp DLL. iTextSharp.text.pdf.PdfWriter writer = iTextSharp.text.pdf.PdfWriter.GetInstance(document, new System.IO.FileStream(destPdf, System.IO.FileMode.Create)); System.Drawing.Bitmap bmp = new System.Drawing.Bitmap(sourceTif); iTextSharp.text.pdf.PdfContentByte cb = writer ...

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( icker) it cannot predict the visibility of low frequency variations that would require an appearance-oriented, rather than JND-oriented, model The Sarnoff model also is not designed for rendering video This is not a criticism of the model formulation, but an illustration of how the objective of the Sarnoff JND model is signi cantly different from that of the iCAM model While it is well accepted in the vision science literature that JND predictions are not linearly related to suprathreshold appearance differences, it is certainly possible to use a JND model to try to predict suprathreshold image differences and the Sarnoff JND model has been applied with some success to such data A similar model, the DVQ (Digital Video Quality) metric has been published by Watson (1998) and Watson et al (2001) of NASA.

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The DVQ metric is similar in concept to the Sarnoff JND model, but signi cantly different in implementation Its spatial decomposition is based on the coef cients of a discrete cosine transformation (DCT) making it amenable to hardware implementation and likely making it particularly good at detecting artifacts introduced by DCT-based video compression algorithms It also has a more robust temporal lter that should be capable of predicting a wider array of temporal artifacts Like the Sarnoff model, the DVQ metric is aimed at predicting the probability of detection of threshold image differences The DVQ model also includes no explicit appearance processing through spatial or temporal adaptation, or correlates of appearance attributes and therefore also cannot be used for video rendering Again, this is not a shortcoming, but rather a property of the design objectives for the DVQ model.

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While color appearance modeling has been successful in facilitating device-independent color imaging and is incorporated into modern color management systems, there remains signi cant room for improvement and extension of capabilities To address these issues with respect to spatial properties of vision and image perception and image quality, the concept of image appearance models has been recently introduced and implemented (Fairchild and Johnson 2002, Fairchild 2002a,b) These models combine attributes of color appearance models with attributes of spatial vision models that have been previously used for image quality metrics in an attempt to further extend the capabilities of color appearance models Historically color appearance models largely ignored spatial vision (eg, CIECAM97s, CIECAM02) while spatial vision models for image quality largely ignored color (Daly 1993, Lubin 1993) Some exceptions include the retinex model (Land 1986, 1964, Land and McCann 1971, McCann et al.

1976) and its various derivatives (Funt et al 2000, Barnard and Funt 1997, Brainard and Wandell 1986) The spatial ATD model (Granger 1993) and the S-CIELAB model (Zhang and Wandell 1996) also address some of these issues to various extents While the retinex model was never designed as a complete model of image appearance and quality, its spatially variable mechanisms of chromatic adaptation and color constancy serve some of the same purposes in image rendering and provide some of the critical groundwork for image appearance modeling..

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